ES is characterized by several different genetic rearrangements, but the most frequent involves the 11th and 22nd chromosomes in t(11;22) (q24;q12), representing a non-random rearrangement between the Ewing sarcoma (EWS) gene and the E26 transformation-specific or E-twenty-six (ETS) gene family, which generates the fusion gene EWSR1-ETS [4]. This evidence concerns the gene EWSR1 and Ewing sarcoma.