EWSR1-FLI1 uses a specific enzyme, named lysine-specific demethylase 1 (LSD1) to repress some critical tumor suppressors, such as lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (LOX1) and transforming growth factor beta receptor 2 (TGFBR2) [50]. Here, FLI1 is linked to neoplasm.