Uni- and multivariable regression analyses, the latter including age, diabetes, hypertension, and active smoking as covariates, confirmed a significant association with the presence of PAD for PMN-elastase (adjusted OR: 1.008; 95%CI: 1.002–1.015; p = 0.006), NGAL (adjusted OR: 1.045; 95%CI: 1.024–1.066; p < 0.001), and MPO (adjusted OR: 1.013; 95%CI: 1.001–1.024; p = 0.028). The gene discussed is MPO; the disease is peripheral arterial disease.