The TNF −238A allele (rs361525) has also been implicated in a number of autoimmune diseases including rheumatoid arthritis [34], ankylosing spondylitis [35], systemic lupus erythematosus [36], juvenile idiopathic arthritis [37], Graves’ disease [38], and type I diabetes mellitus [39]. This evidence concerns the gene TNF and type 1 diabetes mellitus.