In the current work, the mechanisms underlying the antidepressant effect of RGZ, such as regulation of AMPK and mTOR, and their downstream signaling pathways of pAKT, p38MAPK, 4EBP1, and NGF, were investigated in a mouse model of depression induced by dexamethasone (DEXA). The gene discussed is MTOR; the disease is depressive symptom measurement.