TNF and COVID-19: Inflammation has a critically important role in the severity of COVID-19 progression [6,7], with elevated levels of inflammatory cytokines as well as CRP secreted under the influence of inflammatory cytokines, such as interleukin-6 and tumor necrosis factor-alpha, observed in patients with severe COVID-19 [39,40], suggesting the involvement of a cytokine storm in severe COVID-19 progression [41].