The results showed that the association of serum uric acid level with severe COVID-19 progression was significantly different from results obtained by analysis with and without inclusion of serum CRP level (HR = 1.337 vs. HR = 1.233; p = 0.041 by bootstrap method), whereas no statistically significant difference was noted for serum KL-6 or plasma D-dimer level, suggesting that inflammation influenced the association of uric acid with severe COVID-19 progression. This evidence concerns the gene CRP and COVID-19.