In HPV-associated and -unrelated TCGA tonsil cancer data, the tendency for CDKN2A (0% vs. 16.7%, respectively), FGFR3 (6.3% vs. 0%, respectively), and RB1 (9.4% vs. 7.9%, respectively) expression was comparable to that observed in our cohort. Here, RB1 is linked to tonsillitis.