HSPB8 and neuropathy: When we introduced PINK1 and Parkin, which translocate to depolarized mitochondria and remodel them to maintain mitochondrial function and integrity, these two genes successfully rescued mitochondrial depolarization and the motor deficits in HSPB8K141T and HSPB8K141E transgenic flies, suggesting that mitochondrial dysfunction has an essential role in HSPB8 mutation-induced neuropathy (Figure 4A,D).