In a study by Rojek et al., it was reported that patients suffering from left ventricular hypertrophy carrying a particular polymorphism in the peroxisome proliferator-activated receptor-γ coactivator-1 α (PPARGC1A) gene had a higher ratio of PICP to procollagen type-III amino-terminal propeptides (PIIINP), a marker to study collagen type III [19]. Here, PPARGC1A is linked to left ventricular hypertrophy.