AQP6 and Alzheimer disease: For example, in HIP, the AQP6 transcript was increased in the AD as compared to the C group (p < 0.05); AQPs 0 and 8 expression levels were higher in the TCx of AD patients than C patients (p < 0.05); and AQP10 expression was increased in AD patients in the PCx (p < 0.001; Figure 4a) as compared to the young control group.