IL1B and infection: Similarly, in another investigation, where mice were trained by a wide range of infections such as S. aureus, L. monocytogenes, E. coli, C. rodentium and P. aeruginosa to mimic systemic infections, peritonitis, enteritis and pneumonia, the ability of mice to exhibit wide-range protective effects from heterologous infections at distant anatomic sites from the training site, particularly regulated by IL-1 pathway, was revealed [71,72].