EMMPRIN is first and foremost a pro-angiogenic factor, as it induces the expression of MMPs and VEGF [28,30], but its ability to interact with different proteins as a hub protein that stabilizes multiprotein complexes implicates it in the regulation of tumor cell proliferation, lactate efflux, cell adhesion, and drug resistance, as well [29,31,32,33]. Here, VEGFA is linked to neoplasm.