In the Huh7 and HepG2 HCC cells, overexpression of EMMPRIN resulted in increased expression of MMPs that cleaved and activated TGFβ, leading to the induced expression of Snail and Slug, the latter being a regulator of EMMPRIN expression, again demonstrating the positive feedback loop between TGFβ and EMMPRIN [34,53]. The gene discussed is SNAI1; the disease is hepatocellular carcinoma.