Indeed, a positive feedback loop has been described between these two proteins in hepatocellular carcinoma cells, whereby TGFβ induces EMMPRIN expression through its effects on Slug, and EMMPRIN can enhance TGFβ bioavailability through its impact on MMPs that cleave pro-TGFβ and also increase TGFβ transcription through β-catenin [53,54]. This evidence concerns the gene TGFB1 and hepatocellular carcinoma.