To understand whether the macrophage mode of activation changes the effects they exert on the tumor cells, we activated RAW 264.7 macrophages for 24 h as M0 (no treatment), M1 (incubation with 100 U/mL IFNγ and 100 ng/mL LPS) or M2 (incubation with IL-4 and IL-13, 20 ng/mL each). This evidence concerns the gene IFNG and neoplasm.