Accumulating data suggest that overexpression of USP5 contributes to tumorigenesis in various cancer types through deubiquitinating and stabilizing oncoproteins, such as p53 in melanoma, c-Maf in multiple myeloma, Slug in hepatocellular carcinoma, or histone deacetylase 2 (HDAC2) in ovarian cancer [12]. The gene discussed is HDAC2; the disease is hepatocellular carcinoma.