VWF deficiency in the context of CF-LVAD occurs either through pump shear-induced VWF activation with subsequent exposure of the ADAMTS-13 cleavage site for enzymatic degradation or by shear stress-induced fragmentation of VWF into dysfunctional small fragments, independent of ADAMTS-13 [4,31,32,33,34]. The gene discussed is VWF; the disease is hyperinsulinemic hypoglycemia, familial, 4.