The beneficial effect of BET inhibition against the neuroinflammatory condition in AD has been further supported by Magistri and colleagues; they found that JQ1 exhibited decreased mRNA expression of pro-inflammatory cytokines and chemokines such as Il-1b, Il-6, Nos2, Tnfa, and Ccl2 in the 3xTg mouse model of AD. This evidence concerns the gene NOS2 and Alzheimer disease.