Supporting data were recently obtained by Quezada and collaborators, showing that the BET inhibitor PFI-1 induced V1-V3 transcripts of the mutant C9ORF72 gene and facilitated the formation of nuclear RNA foci with a consistent reduction in DPR inclusions in cell models of C9ALS/FTD. The gene discussed is DNER; the disease is frontotemporal dementia.