ABCA1 and familial hypercholesterolemia: For example, reduced expression of the transporter genes ABCA1 and ABCG1 was found in the peripheral blood mononuclear cells (PBMC) of individuals with primary (non-familial) hypercholesterolemia treated with statins (atorvastatin and ezetimibe + simvastatin in doses of 10 mg/day/4 weeks for each group) [39].