We previously reported that androgen deprivation therapy (ADT) or anti-androgens results in the activation of the TLK1B>NEK1>YAP1 pathway and induction of EMT and stemness genes, which we proposed to be critical for mCRPC progression and correlated with bioinformatics analyses of PCa data in TCGA [9]. The gene discussed is NEK1; the disease is posterior cortical atrophy.