YAP1 and posterior cortical atrophy: In PCa, YAP1 has been identified as a binding partner of Androgen Receptor (AR) and co-localized with AR in an androgen-dependent manner and in an androgen-independent (AI) manner in Castrate Resistant Prostate Cancer (CRPC) [5] YAP was also found to be upregulated in LNCaP-C42 cells and, when expressed ectopically in LNCaP, activated AR signaling and conferred castration resistance, motility, and invasion (reviewed in [4]).