To determine if the expression of pYAP1 is more crucial in human Pca to detect the stage of cancer, we tested a group of Pca biopsies of different Gleason grades to study if the phosphorylation of YAP1-Y407 could mark a specific stage of cancer progression, particularly where YAP1 nuclear localization may indicate its co-transcriptional role as opposed to its cytoplasmic indolent function [32]. The gene discussed is YAP1; the disease is posterior cortical atrophy.