Similarly to CHRNA1, genes encoding for the two thymoma-associated autoantigens RYR1 and TTN were expressed at lower levels in MG compared to non-MG thymomas, with RYR1 being mainly down-regulated in the MG A/AB subset, and TTN in the MG A/AB and B3/B3 mixed subset. The gene discussed is TTN; the disease is myasthenia gravis.