Indeed, since intra-thymic autoantigen expression is crucial for the establishment and maintenance of self-tolerance by the negative selection of T cells and differentiation of protective Tregs [32,33], reduced AChR-α expression can impair the negative selection of autoreactive T cells and/or contribute to the deficiency of AChR-α-specific Tregs, in turn favoring autoimmunity [24]. Here, CHRNA1 is linked to Autoimmunity.