RYR2 and myasthenia gravis: Indeed, (i) CHRNA1 was 3.0-fold more expressed in MG than non-MG thymomas; (ii) expression levels of the medium-sized neurofilament (NEFM), which exhibits immunogenic similarities with AChR-α and TTN, showed a 23.8-fold increase in MG compared to non-MG thymomas; and (iii) the main neuronal RYR3, which shares homology with muscular RYR1 and cardiac RYR2, was also up-regulated (5.5-fold) in MG thymomas [27].