RYR1 was also down-regulated in thymomas from anti-RYR1 antibody-positive MG patients with B3/B3 mixed thymomas, who showed a down-regulation of AIRE and an up-regulation of RYR3, compared to thymomas of the same type in seronegative non-MG patients (Figure 7a). This evidence concerns the gene RYR1 and myasthenia gravis.