Based on the previously reported similarity of NEFM with AChR-α and TTN, of RYR3 with RYR1, and of HSP60 with AChR-α [27,28,29,30], we addressed the hypothesis that the altered expression of these muscle-like autoantigens in the hyperplastic and neoplastic MG thymic microenvironment could underlie the intra-thymic autosensitization phenomena toward muscle antigens via molecular mimicry. This evidence concerns the gene RYR3 and myasthenia gravis.