Of interest, by constructing a comprehensive atlas of thymoma using bulk and single-cell RNA-sequencing, Yasamizu and colleagues [48] recently demonstrated that MG thymomas are characterized by tumor mTECs with an atypical expression profile of neuron-associated molecules, including both NEFM and RYR3, thus strengthening the idea that changes in the expression of these muscle-like neuron-related proteins are due to tumor TECs. The gene discussed is RYR3; the disease is neoplasm.