CHRNA1 and myasthenia gravis: The reduced CHRNA1 expression we observed in MG thymuses was also in agreement with data showing that the biallelic variant rs16862847, which is associated with early-onset MG, is able to prevent the binding of the interferon regulatory factor 8 to the promoter of CHRNA1 and abrogate the promoter activity in TECs in vitro [18].