Accordingly, we found a significant RYR3 overexpression in MG, particularly of type B3/B3 mixed, along with A/AB, compared to non-MG thymomas, hyperplastic MG, and control thymuses, thus suggesting an association between RYR3 overexpression and autoreactivity to RYR1 developing inside the thymoma. This evidence concerns the gene RYR1 and thymoma.