To address the hypothesis of “HSP60-AChR-α cross-reactivity” [30] in MG patients, we assessed the presence of anti-Hsp60 IgG antibodies in pre-thymectomy sera from AChR-MG patients with thymic follicular hyperplasia and thymomas, seronegative MG patients, and healthy controls. The gene discussed is CHRNA1; the disease is myasthenia gravis.