If only patients with an unmeasurable PSA level at the first measurement, with ISUP 1–4 and no lymph node metastases (pN0/pNx) were considered, 77% of PSA tests could be omitted at 5–8 months after surgery at the downfall of missing BCR in 0.7% of patients. The gene discussed is KLK3; the disease is metastatic malignant neoplasm in the lymph nodes.