GFAP and Alzheimer disease: In a work from Salvadó et al. (2022) [32], the positive GFAP/glucose consumption association turned negative when switching from isolated amyloidopathy (A+T-) to patients with full-blown AD (hence, with tauopathy: A+T+), which they interpreted as an uncoupling of astrogliosis from metabolism due to failure to sustain elevated energetic demands when tauopathy sets in.