Conversely, the presence of GFAP-related astrogliosis in the frontal lobe could either be an epiphenomenon resulting from astrocytic dysfunction in other areas—incapable of sustaining higher metabolic demands—or rather be specifically aimed at preserving functions in the frontal cortex in the course of symptomatic AD, supporting the hypothesis of its delayed involvement. The gene discussed is GFAP; the disease is Alzheimer disease.