NRCT includes the administration of 5-FU or capecitabine, which has been shown to downregulate the inhibitory immune checkpoint, cytotoxic T-lymphocyte protein 4 (CTLA-4), in colorectal cancer cells, thereby regulating the antitumoral immune response and possibly resulting in its therapeutic antitumor effect [3]. The gene discussed is CTLA4; the disease is colorectal cancer.