MAPK8 and myocardial infarction: JNK suppression by peptide and synthetic inhibitors such as d-JNKI-1, AS601245, SP600125, SU3327, and SR 3306 early after I/R myocardial injury has been shown to decrease myocardial infarct size and attenuate cardiomyocyte apoptosis [26,27,28,29,30,31,32].