Among their top 10 most significant proteins that were altered after treatment were the same proteins that we found in our OPLS and OPLS-DA models for depression and anxiety (CXCL6, STAMPB, CXCL1, SIRT2, AXIN1, CXCL5, ST1A1, and IL-7). This evidence concerns the gene SIRT2 and depressive symptom measurement.