HPSE and retroperitoneal sarcoma: Heparanase overexpression (driven in human cancers by numerous molecular pathways [4,5,6,7,8]) is closely associated with enhanced aggressiveness and a poorer prognosis in several types of tumors, notably gastric [9]; colon [4]; ovarian [5] and cervical [6] carcinoma and retroperitoneal sarcoma [10].