In addition, we found that T cell activation and antigen presentation genes were also highly expressed in the subgroups of GC patients, with LKB1high expression, and T (CD3+CD8+LKB1+, CD3+CD8+CD28+LKB1+) cells had a positive correlation with IFN−γ expression in fresh tissues of GC patients. Here, CD28 is linked to gastric cancer.