The aim of this research was to clarify the connection between degeneration of dopaminergic neurons, motor and cognitive deficits with glutamate and insulin signaling in relation to the brain regions involved in cognition (hippocampus), motor function (striatum) and metabolism (hypothalamus) in an animal PD model induced by bilateral intrastriatal 6-OHDA application. This evidence concerns the gene INS and Parkinson disease.