TP53 and head and neck squamous cell carcinoma: On the other hand, in the classical subtype, which is known to be the least aggressive HNSCC subtype, it was noticed that most correlations were slightly positive and in one case there was a statistical significance: TP53 and YRNA4 were significantly correlated with each other (ρ = 0.4833, p = 0.0079) (Figure 2B).