PLA2G12A and airway hyperresponsiveness: The CpG genome-wide, significantly associated with FeNO in whole blood and cross-validated in nasal samples (cg12835256), is located at the gene encoding for phospholipase A2 Group XIIA (PLA2G12A), a member of a group of phospholipases with a key role as regulators of type-2 inflammation, airway hyperresponsiveness, and eicosanoids production in asthma [35].