IL5 and asthma: Regarding the EWAS of BDR, the gene-set enrichment analysis revealed enrichment in several pathways relevant to asthma, including IL-5 (FDR = 1.1 × 10−2), IL-2 (FDR = 4.2 × 10−2), Fc epsilon Receptor I signaling pathways (FDR = 3.3 × 10−2), and cellular aging (FDR = 4.2 × 10−2) (Supplementary Table S6).