INS and Hyperglycemia: However, the dysregulation of key regulatory enzymes, such as glucose-6 phosphatase or phosphoenolpyruvate carboxylase, may contribute to uncontrolled gluconeogenesis in the presence of hyperglycemia or decreased insulin levels; although in our study, we did not observe any difference in insulin levels between the two genotypes, we measured it a few days after the OGTT and ITT.