Although in a study on LGI1 encephalitis no significant difference was observed between levels of T-tau, P-tau181 and NFL from CSF samples taken before or after initiation of immunosuppressive treatment [140], in NSA-AEs reduced CSF levels of T-tau have been reported following immunosuppressive treatment, while the normalization of CSF NFL levels paralleled the resolution of MRI abnormalities [139]. This evidence concerns the gene NEFL and viral encephalitis.