The small molecule AC1903, also known as A498, has been shown to inhibit several TRPC channels, including endogenous TRPC1:C4 channels, TRPC3, TRPC4, TRPC5, TRPC6, TRPC4-C1, and TRPC5-C1 in A498 kidney cancer cells. The gene discussed is TRPC4; the disease is kidney cancer.