PTEN and neoplasm: The increased proliferation and in vitro resistance to trastuzumab mediated by Pnck was partially reverted by knocking down PTEN (phosphatase and tensin homolog), although no clear explanation of this paradoxical effect was given; this phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase mostly acts as a tumor suppressor, although the authors of this work hypothesized the possibility that Pnck could augment the activity of residual PTEN [94] but without providing any experimental evidence.