In this context, it was demonstrated that in conditional CaM-KO chicken pre-B lymphoma DT40 cells (clone ET1-55) stably transfected with the human EGFR, the addition of TET induced a time-dependent downregulation of the cellular levels of CaM, which was accompanied by the progressive inhibition of the EGF-dependent activation of the receptor [44]. The gene discussed is CALM1; the disease is lymphoma.