Notwithstanding the canonical CaM-dependent phospho-Ser/Thr-directed activity of calcineurin (reviewed in [99]), an old report described that this phosphatase was able to dephosphorylate phospho-Tyr-casein/histone prepared in the presence of EGF with a membrane fraction from human epidermoid A431 tumor cells [100], which is a cell line that overexpresses the EGFR. This evidence concerns the gene CALM3 and neoplasm.