Lastly, vitamin C treatment has been shown to reduce cancer cell proliferation in the mutant IDH1-related AML model, in which demethylation occurred in the loci of myeloid differentiating factors, indicating that vitamin C treatment can induce epigenetic reprogramming and offset the effect of 2HG in the TET demethylase activation pathway [118]. Here, IDH1 is linked to acute myeloid leukemia.