MUC16 and cancer: Currently, the combination of CA125 serum analysis and transvaginal ultrasonography (TVS) is the most utilized tool for the initial evaluation of suspect cases, even though CA125 lacks specificity (as it rises due to several physiological and pathological conditions in addition to cancer [16]), and TVS can identify adnexal masses, but is less reliable in differentiating benign from malignant tumors [17].