The serum IL-1β and IL-18 levels in the gout patients were significantly higher than in the controls (7.31 ± 11.84 vs. 0.46 ± 0.91, p = 0.004 and 100.51 ± 47.63 vs. 68.49 ± 32.55, p = 0.002, respectively). This evidence concerns the gene IL18 and gout.