In a comparison of CXCR4 and its ligand CXCL12, the gout patients showed a larger increase in the expression of the serum CXCL12 level compared with the controls (392.27 ± 247.54 vs. 243.90 ± 184.03, p = 0.010). The gene discussed is CXCR4; the disease is gout.