The observation that the administration of 4% albumin reduces oxidative stress, mortality, and endothelial and kidney dysfunctions in mice subjected to endotoxemia, which is induced by labile heme, supports the protective role towards sepsis of HSA [125,126], by reducing heme-mediated in vitro cytotoxicity and in vivo heme-mediated vasoconstriction [115]. Here, ALB is linked to serum lipopolysaccharide activity.