RHOH and heart failure: Transfection of miR-152-3p mimics significantly reduced the luciferase activity of E26 transformation specific-1 (ETS1)-3’UTR-wt, while ETS1 regulates Ras homolog gene family member H (RhoH) in myoblasts, and DNMT1 may inhibit miR-152-3p expression by promoting methylation inhibition of miR-152-3p and enhancing the expression of ETS1, thereby inducing RHOH transcription activation and inhibiting mitochondrial autophagy, ultimately promoting the development of heart failure [199].