Considering that inflammation biomarkers were found in subjects with depression, and also, the extrinsic coagulation pathway was linked with depression [2,45], the data from our research results depict that both coagulation and inflammation-specific molecules like LA, Anti RIB P, ACL, C4, PAI 1 and hs CRP are linked with depression and anxiety. The gene discussed is C4A; the disease is depressive symptom measurement.