Since many factors can influence the immune response of the body to SLE and the presence of neuropsychiatric manifestation is not fully understood from a pathophysiological perspective, our research aims to identify the connection between depression and anxiety and biomarkers possibly associated with NPSL for thrombosis antiphospholipid antibodies, PAI-1, P-selectin, ICAM 1 and among Anti RIB P antibodies. This evidence concerns the gene SELP and major depressive disorder.