The non-flavonoid polyphenol curcumin decreases heat shock protein-60 (Hsp60) and hexokinase II (HK-II) levels and increases Bcl-2 associated agonist of cell death (Bad), phosphatase and tensin homolog (PTEN), and ROS in NB cells [77]. The gene discussed is HSPD1; the disease is neuroblastoma.