Ceramides have been shown to promote the dephosphorylation of SR proteins, resulting in an increase in the pro-apoptotic splice variants Bcl-xS and Caspase 9a and a decrease in the anti-apoptotic splice variants Bcl-xL and Caspase 9b in lung adenocarcinoma cells [89,90]. Here, BCL2L1 is linked to lung adenocarcinoma.