Most lncRNAs accelerated or attenuated NAFLD progression mainly through sponging microRNA (e.g., uc.372, uc.333, CCAT1, lnc-SPARCL1-1:2, NEAT, PVT1, and MALAT1) [20,21,22,23,24,25] or by directly targeting related proteins. Here, SPARCL1 is linked to metabolic dysfunction-associated steatotic liver disease.