Recent studies showed that HFD could significantly increase the histone H3 trimethylation at lysine 4 (H3K4Me3) [62] while increased H3K4Me3 level at the interleukin 6 (Il-6) promoter region could promote its expression which subsequently contributed to lung fibrosis through enhancing EMT [63]. The gene discussed is IL6; the disease is pulmonary fibrosis.