Several genes associated with inflammation, including TNF-α, CCAAT enhancer binding protein beta (Cebpb), the nuclear factor kappa light chain enhancer of activated B cells (NF-kB) pathway, and neuroplasticity factors, including BDNF and transforming growth factor beta (TGF-β), are predicted targets for miR-155, two major pathways that are dysregulated in major depressive disorders [34]. The gene discussed is BDNF; the disease is major depressive disorder.