In contrast, the expression of LIPN was down-regulated in pathways of alanine, aspartate, and glutamate metabolism, aminoacyl-tRNA biosynthesis, arginine and proline metabolism, biosynthesis of amino acids, DNA replication, ECM-receptor interaction, glycine, serine and threonine metabolism, Hypertrophic cardiomyopathy, Primary immunodeficiency, and Tryptophan metabolism (Figure 6C). Here, LIPN is linked to inborn error of immunity.