Recently, our group reported that the increase in the circulating levels of TNFR2 were associated with renal function decline, suggesting that the TNF-α inflammation pathway reflects disease progression [14]; moreover, TNFR2 appeared to be useful for an early detection of CKD, presenting a significantly higher value, as compared to the control group. The gene discussed is TNFRSF1B; the disease is chronic kidney disease.