Since sTNF-R1 acts as a decoy receptor to inhibit TNF-induced signaling [13], it is possible that predementia subjects with higher sTNF-R1 levels may be protected from cognitive decline resulting from TNF-mediated neuroinflammatory or neurovascular injuries, as higher CSF levels of TNF were found to be associated with conversion to dementia [45]. The gene discussed is TNF; the disease is Mental deterioration.