SFRP1 and carcinoma: In addition, we found that OH-BBN treatment increased the expression of some LSD1 target genes, including sFRP1, Hox c8, c11, and c13, and Hox d1, and that the kawain diet reversed the effects of OH-BBN on the expression of LSD1 targeted genes in bladder tumor tissues of the OH-BBN bladder carcinogenesis model (Figure 6).