Zheng and colleagues observed that through binding miR-181a-5p, lncRNA myocardial infarction-associated transcript (MIAT) negatively regulated miR-181a-5p expression and partially attenuated miR-181a-5p inhibition upon the expression level of OPN, suggesting that MIAT competitively binds to miR-181a-5p to counteract miR-181a-5p-mediated suppression of OPN. The gene discussed is SPP1; the disease is myocardial infarction.