With adjustment for age, sex, BMI, pre-existing renal impairment, hypertension, diabetes, and baseline covariates with a p-value of <0.1 in the univariate analyses via the enter method, our analysis demonstrated that the post-procedure ratios of urinary IL-18 and GSN during the early post-procedure period were independently associated with the occurrence of AKD after cardiac catheterization (odds ratio (OR) (95% confidence interval (CI)), 4.742 (1.523–14.759) for IL-18 ratio, p = 0.007; 1.812 (1.027–3.198) for GSN ratio, p = 0.040). Here, IL18 is linked to Hypertension.