HK1 and Parkinson disease: Such discoveries include the function of UPRER as a modulator of tau aggregation, the participation of SUT-1 and SUT-2 in the activation of tau, the protective effect of the glycolytic enzyme GPI against α-syn toxicity, the tendency of dopamine to exacerbate α-syn induced neurotoxicity, as well as the nature of autophagy and mitophagy as substantial factors in the pathogenesis of PD and other neurodegenerative disorders [72,73,74,98,197,198,199,200,201].