The most renowned examples of such discoveries include the potential of using α-Methyl-α-phenylsuccinimide (MPS) as a treatment for TDP43-related proteinopathies, the identification of neuroleptics as promising anti-ALS compounds that stabilize neuromuscular transmission, and the suggestion that LRKK2 inhibitors can be used as effective drugs against PD [113,189,190]. The gene discussed is TARDBP; the disease is proteostasis deficiencies.