Recent studies indicated that mitophagy, a selective form of autophagy that targets damaged and/or superfluous mitochondria, is impaired in AD patients and relevant animal models, including C. elegans. Indeed, the administration of potent mitophagy inducers, such as nicotinamide adenine dinucleotide (NAD+) boosters or urolithin A (UA), reverses memory impairment and cognitive deficits in Aβ- and tau-expressing C. elegans models [36]. This evidence concerns the gene MAPT and Alzheimer disease.