Although primary glioblastoma tumors are reported to express significantly low levels of RAS transcripts and no detectable levels of RAS proteins [108], analysis of gene expression of human glioma tissue samples deposited in the REMBRANDT database clearly implicates a correlation between upregulation of RRAD in EGFR-expressing glioma patients and poorer prognosis [34]. This evidence concerns the gene EGFR and central nervous system cancer.